医学博文特发性肺动脉高压及系统性硬化

翻译：和平校对：审核：张莉芸

Abstract

Pulmonaryarterialhypertension(PAH)representsoneofthemainclinicalexpressionsofthevascularchangesinsystemicsclerosis(SSc).LungmicrovascularchangescanplayaroleinthepathogenesisofidiopathicPAH(IPAH)also.TheaimofthisstudyistoinvestigatethepresenceofcapillaroscopicabnormalitiesinpatientswithIPAHandtoevaluatethedifferencesincapillarynailfoldchangesbetweenpatientswithIPAHandpatientswithSScwithandwithoutPAH.

METHODS:

39SScpatients(19withPAH-SSc-PAHand20without-SSc-noPAH),21subjectswithIPAHand20healthysubjectswererecruited.PAHwasdiagnosedbyrightheartcatheterization.Nailfoldvideocapillaroscopywasperformed(NVC)inallrecruitedsubjects;capillaryquantitativeparameters(loopslengthandwidth,capillarydensity,neoangiogenesis)wereevaluatedandasemiquantitativescoringwasused(normal,minorormajorabnormalitiesforhealthycontrolsandIPAHsubjectsandspecificpatterns-early,activeandlate-forSScsubjects)todefinemicrovascularalterations.

RESULTS:

Thepresenceofcapillaroscopicabnormalitieswasdetectedin38,1%subjectswithIPAH;particularly,







































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