研究证实PAH P-EC增殖超过了对照细

objectivesthis study sought to test the hypothesis that nebivolol, aβ1-antagonist and β2,3-agonist, may improve pah and reverse the pah-relatedphenotype of pulmonary ecs (p-ec).

奈必洛尔或有望治疗肺动脉高压

backgroundendothelial cell (ec) dysfunction plays a central role in thepathogenesis of pulmonary arterial hypertensi肺动脉高压治疗医院on (pah), promotingvasoconstriction, smooth muscle proliferation, and inflammation.

(英文原文)nebivolol for improving endothelial dysfunction, pulmonary vascularremodeling, and right heart function in pulmonary hypertension

近日一项研究显示,奈必洛尔或有望治疗肺动脉高压(pah),改善内皮功能障碍、肺血管重构以及右心功能然而,在进行临床试验以前,不建议常规使用β-阻滞剂治疗pah

结果显示,与对照细肺动脉高压值多少胞相比,pah p-ec过度表达促炎介质白介素-6和单核细胞化学引诱物蛋白-1、成纤维细胞生长因子-2以及强效血管收缩物内皮素-1奈必洛尔可修正这种病理表型但美托洛尔不能研究证实pah p-ec增殖超过了对照细胞,并可刺激更多的肺动脉平滑肌细胞有丝分裂(一种生长异常,奈必洛尔可以使之恢复正常,而美托洛尔不行)在改善野百合碱诱导的pah小鼠心功能、肺血管重构以及炎症方面,奈必洛尔比美托洛尔更强效

conclusionsnebivolol could be a promising option for the management ofpah, improving endothelial dysfunction肺动脉高压会议肺动脉高压, pulmonary vascular remodeling, andright heart function. until clinical studies are undertaken, however, routineuse of β-blockers in pah cannot be recommended.

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results pah p-ecs overexpressed the proinflammatory mediatorsinterleukin-6 and monocyte chemoattractant protein-1,fibroblast growt肺动脉高压症治疗h factor-2, and the potent vasoconstrictive agentendothelin-1 as compared with control cells. this pathological phenotype wascorrected by nebivolol but not metoprolol in a dose-dependent fashion. weconfirmed that pah p-ec proliferate more than control cells and stimulate morepa smooth muscle cell mito肺动脉高压肿瘤sis, a growth abnormality that was normalized bynebivolol but not by metoprolol. nebivolol but not metoprolol inducedendothelium-dependent and nitric oxide–dependent relaxation of pa. nebivololwas more potent than metoprolol in improving cardiac function, pulmonaryvascular remodeling, and inflammati中医治疗肺动脉高压on of rats with monocrotaline-inducedpulmonary hypertension.

methods we compared the effects of nebivolol with metoprolol, afirst-generation β1-selective β-blocker, on human cultured pah and control p-ecproliferation, vasoactive and proinflammatory factor production, and crosstalkwith pa smooth muscle肺动脉高压 轻度 cells. we assessed the effects of both β-blockers inprecontracted pa rings. we also compared the effects of both β-blockers inexperimental pah.

2015-03-03长城国际心脏病学会议长城国际心脏病学会议

来源:cardiosource journal scans(february 18,2015)

【学术2015-051】奈必洛尔或有望治疗肺动脉高压

长城国际心脏病学会议

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内皮细胞(ec)功能障碍在pah的发病机制中具有重要作用,其可促进血管收缩、平滑轻度原发性肺动脉高压肌增生并引发炎症本研究旨在验证奈必洛尔可能改善pah并逆转pah相关肺ec表型(p-ec)的假说,比较奈必洛尔和美托洛尔对人培养pah和对照p-ec增殖、血管、促炎因子生成以及肺动脉平滑肌细胞串扰的作用
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