(英文原文)NebivololforImprovingEndothelialDysfunction,PulmonaryVascularRemodeling,andRightHeartFunctioninPulmonaryHypertension
BackgroundEndothelialcell(EC)dysfunctionplaysacentralroleinthepathogenesisofpulmonaryarterialhypertension(PAH),promotingvasoconstriction,smoothmuscleproliferation,andinflammation.
ObjectivesThisstudysoughttotestthehypothesisthatnebivolol,aβ1-antagonistandβ2,3-agonist,mayimprovePAHandreversethePAH-relatedphenotypeofpulmonaryECs(P-EC).
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