综述分享COPD患者发生肺动脉高压的生理

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您好，我是Luka。

今天分享的内容，来自于年最新的一篇关于肺动脉高压的综述，主要分享关于肺动脉高压在COPD患者中的生理病理机制这一部分。

分享内容绝大部分都是自己编辑的，主要用英文来写作。第一次尝试做这类型的分享，水平有限，如果错误或不当，还望海涵。

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04.23

目录

01)informationofthisreview

02)Questionsorobjectivesofthisreview

03)PhysiologicalandpathologicalmechanismsandtheprevalenceofPHinCOPDpatients

01

informationofthisreview

PulmonaryHypertensioninChronicObstructivePulmonaryDisease

NorbertWeissmann,etc.

BritishJournalofPharmacology

10./bph.

02

Questionsorobjectives

①TheunderlyingmechanismsofhowPHisassociatedwithincreasemortalityandmorbidityinCOPDremainelusive.

ThisreviewisgoingtosummarizethecurrentunderstandingofthepathophysiologyofPHinCOPD.

②specificandefficienttreatmentoptionsarenotavailable.

Inthisarticle,theauthorswillgiveanoverviewoftheavailabletreatmentoptionsandrecentadvancesinpreclinicalstudies

03

PhysiologicalandpathologicalmechanismsandtheprevalenceofPHinCOPDpatients

1.MechanismsofPAPelevationinCOPD

2.Cardiovascularfactorsandtreatment

3.IncreasedPVR

4.Tobaccosmoking,endothelialandepithelial

dysfunction,andinflammation

5.Geneticheterogeneity

MechanismsofPAPelevationinCOPD

include:

①hyperinflationofthelung

②anincreasedfillingpressureoftheleftventricle

③elevatedPVR

Cardiovascularfactorsandtreatment

①ReducedRVvolumesinpatientswithmildtomoderateCOPDcanbeexplainedbyincreasedintrathoracicpressures,andthiscanbereversedbyusing